The Regional Health Governance Study (RHGS) is a multidisciplinary initiative that investigates how regional frameworks can strengthen equitable pandemic preparedness and health governance across regions. Emerging from the recognition that COVID-19 revealed deep inequities and fragmentation in global health systems, the RHGS explores how regional institutions such as Africa CDC can complement and enhance the global governance institutions such as WHO. By bridging global health law, policy, and human rights, the project aims to develop a regionalized model of pandemic management that decentralizes decision-making, enhances solidarity among member states, and strengthens institutional accountability. It operates as both a research platform and a vehicle for knowledge mobilization, engaging scholars, policymakers, and civil society partners in co-producing solutions that advance health equity, human rights, and governance resilience.